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According to the recent report from a medical journal (International Journal of Clinical Practice - IJCP) published in April, 2005 (Ref. 1), schizophrenia is a chronic disabling disease that often results in drastically impaired quality of life. The majority of patients with schizophrenia require long-term treatment with antipsychotics. The pharmacotherapy can be divided into typical (old version) and atypical (new version) drugs.
Before the development of atypical antipsychotics, treatment choice was restricted to conventional (or typical) antipsychotics, which are known to cause a range of side effects including extrapyramidal symptoms (EPS). Although atypical agents provide a favourable alternative (advocated by the National Institute of Clinical Excellence in the UK) because of the lower incidence of EPS, they are still associated with side effects such as weight gain, sedation and hyperprolactinaemia.
The Schizophrenia Innovation Working Group of the medical report (IJCP) suggested that compared with available antipsychotics, Aripiprazole may offer a useful alternative for patients for whom weight gain, EPS and sedation are barriers to long term treatment. |
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Ref. 1:Int J Clin Pract,April 2005,59(4)485-495 |
Ref. 1: The San-In Group of Liver Surgery: British Journal of Surgery , 1997; 84:1525-1531
Ref. 2: Ichida T., et al: Nutrition, 1995; 11:238-244
Ref. 3: Meng W.C.S., et al: Aust. N.Z.J. Surg., 1999; 69:811-815
Ref. 4: Poon R.T.P., et al : Aliment Pharmacol Ther 2004; 19:779-788 |
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